The eFORGE TF application is an adjunct to the eFORGE EWAS analysis tool. This enables the exploration of DNase I tag (chromatin accessibility) signal surrounding methylation array probes and the calculation of significance of overlap with transcription factor binding sites from common TF databases.
Settings
Mode
View associations of transcription factors (TF) and footprints with an individual probe, or a summary of TF associations over all probes, with positional overlap of selected probes with associated TFs
Array
Sample
Padding
1
20
50
100
200
500
Padding (nt) around the probe genomic location
Smoothing
2
0
1
2
3
5
Smoothing window padding (nt)
Signal rendering
Display signal as bar chart ("density") or as line chart with cubic spline
TF overlaps
Display probe-specific or all transcription factor overlaps ("All" can increase query time)
Probe IDs
Probe IDs may be separated by commas or newline characters (max. 1000)